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Radionuclide imaging in epilepsy

Beate Diehl epilepsy Francesco Fraioli Maria Vittoria Mattoli NM nuclear medicine PET PETCT radionuclide SPECT

Epilepsy is one of the most frequent chronic neurological disorders, with an incidence of 50/100,000/year and a prevalence of 0.5-1% in Western society. One third of patients with epilepsy have seizures that do not respond to medical treatment leading to cognitive decline, poor quality of life, high societal costs and significantly increased mortality including sudden unexpected death in epilepsy (SUDEP), resulting in 1 in 200 deaths per year in those with drug-resistant epilepsy.

Surgery, aiming to remove the seizure onset zone (SOZ) with the preservation of the eloquent areas, can potentially offer a cure for those who cannot achieve seizure control on medication alone. The surgical approach can be highly effective in treating refractory epilepsy if performed in appropriately selected patients with well-delineated epileptic foci.

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