The voice of medical imaging and clinical oncology

PETCT in lymphoma

Hodgkin lymphoma lymphoma Mark Hughes Nagabhushan Seshadri PETCT Rashika Fernando

Lymphomas can be broadly divided into Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). There are over 60 subtypes of NHL and in this heterogeneous group of malignancies, two of the most common subtypes are diffuse large B-cell lymphoma (DLBCL) representing the high grade or histologically aggressive lymphomas, and follicular lymphoma (FL) which is low grade lymphoma. The other main NHL subtypes are marginal zone lymphoma (9%), mantle cell lymphoma (6%), T-cell lymphoma (7%) and Burkitt’s lymphoma (1%). The histological subtype and molecular characteristics determine the behaviour pattern and generally, while there is an increased risk of early death with high grade lymphomas, the majority achieve remission with less chance of relapse. Low grade lymphomas have a more indolent clinical course, and can attain remission, but the relapse rates are higher.

HL can be classified into nodular lymphocyte predominant (NLPHL) and classical HL which in turn has four subtypes. NLPHL is more common in immunocompromised patients and linked with Epstein-Barr virus. NLPHL has a risk of transforming into a high grade NHL.

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