Neuroblastoma imaging

Author(s): Kieran McHugh, Piers Osborne

Hospital: Great Ormond Street Hospital for Children NHS Trust, London

Reference: RAD Magazine, 44, 522, 27-28


Neuroblastoma (NBL) is the most common extra-cranial solid tumour in children. NBLs are of ganglion cell origin and originate from primordial neural crest cells that would subsequently form the sympathetic nervous system. NBLs can vary widely in their clinical course, with some tumours being highly aggressive while others, typically in infancy, spontaneously regressing. There is a spectrum of disease with increasingly poor prognosis (as cell differentiation decreases) from ganglioglioma through ganglioneuroblastoma to NBL. Factors that affect outcome are the age of the child, the underlying biology of the tumour and the disease stage at diagnosis.

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