Ultrasound in translational research – of mice and men

Ultrasound imaging applied to preclinical animal models provides unique insights into the development and mechanisms of many clinical diseases. The sequencing of the mouse genome and the resultant ability to be able to modify the genetic footprint of these small animals, coupled with their short gestation periods and high reproduction rates, make them the model most often utilised in translational research. In the UK, all animal studies are performed under the Animals (Scientific Procedures) Act (ASPA) 1986, which safeguards laboratory animal welfare while allowing research to continue. Statistics are released by the Home Office detailing the number of scientific procedures on living animals that take place each year in Great Britain.

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