Is 68Ga-DOTA-PETCT more accurate than 123I/131I-mIBG imaging in the diagnosis of phaeochromocytoma?

Phaeochromocytoma is a rare neuroendocrine tumour (NET), with an annual incidence of approximately 1/100,000. Arising from the adrenal medulla, phaeochromocytomas constitute approximately 80-85% of all chromaffin cell tumours. Phaeochromocytomas secrete excessive catecholamines, inducing hypertension and tachycardia.

Provisional diagnoses are made following clinical examination and biochemical analysis, with anatomical imaging to localise the tumour and functional imaging to characterise and assess for metastases. Functional imaging is critical as anatomical imaging lacks specificity in differentiating tumour types, and histological analysis cannot differentiate benign from malignant, a diagnosis of which is made upon visualisation of metastases.

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