Myocardial perfusion PET is a well established technique for assessing obstructive coronary artery and coronary microvascular diseases. It has been shown to be superior to SPECT imaging in image quality, prognostic information, scan time and lower radiation dose for both the patient and operators. Through the creation of dynamic images, PET also provides the ability […]
Dr Ian Armstrong
Manchester University NHS Foundation Trust
Prostate cancer is the second most common cancer in the world, predicted to rise by 15% by 2025, while detection in late stage disease increased from 3.9% to 8.2% over the past decade in the USA. Primary investigations for clinical diagnosis and staging of prostate cancer include blood tests, biopsy and imaging techniques such as […]
Rayjanah Allie, Dr Dimitris Priftakis, Professor Jamshed Bomanji
University College London Hospitals NHS Foundation Trust
Management for differentiated thyroid cancer (DTC) has seen significant changes over the last decade. The approach is dramatically shifting to personalised based rational decisions. This includes, but is not limited to, the extent of surgery, active surveillance in low risk very limited disease, radioiodine (RAI) ablation or no ablation after initial surgery, low iodine activity […]
Dr Fahim Ul Hassan
Guy's and St Thomas' NHS Foundation Trust
Theragnostic nuclear medicine is a much discussed topic in nuclear medicine and is currently discussed and debated in clinical oncology with great interest and optimism. Radionuclide theragnostics generally pairs diagnostic biomarkers with radiolabelled therapeutic agents that share a specific target within the diseased cells or tissues. The clinical indications are expanding, with evolving evidence. Incorporating […]
Dr Gopinath Gnanasegaran, Dr Shaunak Navalkissoor
Royal Free London NHS Foundation Trust
Foot and ankle injuries are common, chronic pain is prevalent and many patients present with symptoms that cannot be fully explained by conventional imaging techniques. This article will explore the increasing role of SPECT/CT in the investigation of common foot and ankle pathologies. Conventional diagnostic techniques such as plain radiography, ultrasound, CT and MRI currently […]
Dr Luke Zhu, Dr Malavika Nathan
West Midlands Deanery; Royal Free London NHS Foundation Trust
Ioflupane (DaTSCAN) is a well established diagnostic tool for diagnosis of Parkinson’s disease (PD), as well as dementia with Lewy bodies (DLB). Ioflupane binds to the dopamine active transporters in the presynaptic membrane of the dopaminergic nerve terminals (DNT). Dopaminergic pathways in the brain are involved in various brain functions. Degeneration of dopaminergic neurons in […]
Dr Alp Notghi, Mr Joseph O'Brien
City Hospital
In 1942 Dr Saul Hertz used 131I radioiodine (RAI) to treat thyroid disease. Although theragnostics (also known as theranostics) was a term not invented at that time, Dr Hertz was using g-rays from RAI as a tracer and diagnostic biomarker, and its b particles for therapy, so he can be regarded as a pioneer. 131I […]
Dr Chris Mayes
Royal Liverpool University Hospital
Hip fractures are a cause of significant morbidity and mortality, particularly in the elderly, and therefore accurate and timely diagnosis and management is essential. If left untreated, the mortality rate of hip fractures is 10% within 30 days, 15% within a year and 40% within two years. The mainstay of diagnosing these fractures is with […]
Dr Anuja Joshi, Dr Yaron Berkowitz
Oxford University Hospitals NHS Foundation Trust
