The voice of medical imaging and clinical oncology

radiotherapy

Radiotherapy late effects in practice

Despite advancements in radiotherapy, many cancer survivors experience late effects that significantly impair quality of life, creating a growing burden on healthcare systems. Historically, focus has been on early diagnosis and acute toxicity, but attention is now shifting toward long-term consequences and patient-centred care. Late effects arise from radiation-induced fibrosis (RIF), a progressive condition causing […]

Emma Hallam

Emma Hallam

Nottingham Radiotherapy Centre, Nottingham University Hospitals NHS Trust

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What is FLASH radiotherapy?

FLASH radiotherapy is an emerging technique in cancer treatment that delivers radiation at ultra high dose rates – typically above 40-50Gy/s – within milliseconds, compared to conventional rates of about 0.03Gy/s over several minutes. The central goal of radiotherapy has always been to maximise tumour control while minimising normal tissue toxicity. Traditional approaches rely on […]

Stephen McMahon

Professor Stephen McMahon, Professor Karl Butterworth

Johnston Cancer Research Centre, Queen’s University Belfast

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Dosimetry to improve molecular radiotherapy outcomes

This article explores the critical role of dosimetry in enhancing outcomes for molecular radiotherapy (MRT), a treatment modality that delivers targeted radiation to cancer cells via radiopharmaceuticals. While MRT has grown significantly in the UK over the past two decades, current prescribing practices often rely on fixed activity or weight-based adjustments, which fail to account […]

Matt Aldridge

Dr Matt Aldridge

King's College Hospital, London; Internal Dosimetry User Group

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Molecular radiotherapy in prostate cancer

Molecular radiotherapy (MRT), also known as targeted radionuclide therapy or radioligand therapy, is emerging as a transformative approach in the treatment of prostate cancer, particularly in metastatic and castration-resistant cases. Unlike traditional external beam radiotherapy, MRT delivers targeted radiation internally using radioactive substances that bind to specific tumour markers, minimising damage to healthy tissue and […]

Dr Amy Eccles

Dr Amy Eccles

Imperial College Healthcare NHS Trust

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Set-up errors to patient comfort in radiotherapy – a journey of discovery

Accuracy in positioning and immobilisation is fundamental in radiotherapy to ensure precise delivery of radiation to the intended target while minimising exposure to surrounding healthy tissues. The study and critique of accuracy or set-up errors across anatomical cancer sites is well established and has driven technique development for many years. Although patients positioned for radiotherapy […]

Simon Goldsworthy

The Beacon Centre Radiotherapy, Musgrove Park Hospital

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Calling time on the end of treatment bell following radiotherapy: the CELEBRATE study

In UK radiotherapy departments it has become common practice for patients to be invited to ring a bell at the end of treatment as a form of celebration. The sound resonates through hospital corridors, marking the end of a challenging journey. Yet, this seemingly celebratory act has sparked debate, with some questioning whether it serves […]

Keeley Rigby

Keeley Rigby

Sheffield Hallam University

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An overview of the PROSECCA project

Up to half of prostate cancer patients receive radiotherapy as part of their treatment and, although it is effective at destroying cancerous lesions deep within the body, this comes at the cost of damaging healthy, or normal, tissues. With 78% of prostate cancer patients surviving for 10 years or more, limiting life-changing side effects for […]

Professor Bill Nailon, Dr David Noble, Zhuolin Yang, Sarah Elliot, Alasdair Rutherford, Dr Tony Hallam, Dr George Beckett, Professor Duncan McLaren

Edinburgh Cancer Centre; University of Edinburgh; Beatson West of Scotland Cancer Centre

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Image-guided and adaptive radiotherapy for cervical cancer

The established treatment for locally advanced cervical cancer is chemoradiotherapy with external beam radiotherapy (EBRT) and weekly Cisplatin followed by intrauterine brachytherapy. Radiotherapy for cervix cancer is associated with acute and long-term toxicity to adjacent pelvic organs (bladder, bowel, rectum) as they lie in close proximity to the radiotherapy target volume of the cervix, uterus, […]

Benjamin Thomas, Susan Lalondrelle

Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London

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