The voice of medical imaging and clinical oncology

Gopinath Gnanasegaran

Nuclear medicine theragnostics: walk before you run

Theragnostic nuclear medicine is a much discussed topic in nuclear medicine and is currently discussed and debated in clinical oncology with great interest and optimism. Radionuclide theragnostics generally pairs diagnostic biomarkers with radiolabelled therapeutic agents that share a specific target within the diseased cells or tissues. The clinical indications are expanding, with evolving evidence. Incorporating […]

Dr Gopinath Gnanasegaran, Dr Shaunak Navalkissoor

Royal Free London NHS Foundation Trust

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Non-FDG PET tracers in oncology: the story so far

The role of radionuclide molecular imaging in oncology with 2-deoxy-2-[fluorine-18] fluoro-D-glucose (18F-FDG) is well established. There is ample evidence to support the role of 18F-FDG PETCT in various clinical scenarios and cancer types. However, there has been a phenomenal expansion in non-FDG PET radiopharmaceuticals for use in clinical oncology. 68Ga is a well established radionuclide […]

Dr Gopinath Gnanasegaran

Royal Free London NHS Foundation Trust

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PETCT imaging in pancreatic neoplasm: FDG and non-FDG tracers

Pancreatic cancer is considered the 10th most common malignancy globally with a poor prognosis (fourth most common cause of overall cancer deaths). The most common age at diagnosis is 65-74 years. The five-year survival rate is approximately 11.5% as per the latest SEER 17 data (ranging from 44% for localised disease to 3% for distant […]

Dr Sai Sradha Patro, Dr Kanhaiyalal Agrawal, Dr Gopinath Gnanasegaran

AIIMS India, Royal Free London NHS Foundation Trust

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Radionuclide bone SPECT/CT in orthopaedics

Radionuclide 99mTc-MDP planar bone scan is the most commonly performed nuclear medicine procedure and may aid diagnosis of benign and malignant bone pathologies. 99mTc-MDP is injected intravenously and subsequently taken up by osteoblasts and incorporated into the bone matrix. In the process it acts as a marker for new bone formation, bone turnover and local […]

Dr Kanhaiyalal Agrawal, Dr Alexis Corrigan, Dr Sanjay Vijaynathan, Dr Gopinath Gnanasegaran

Guy's and St Thomas' Hospital NHS Foundation Trust

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Radionuclide SPECT/CT in oncology

Radionuclide imaging employs radiolabelled tracers in the investigation of suspected cancer, subsequent staging, response assessment and the assessment of recurrence. Highly specific tracers, that target cellular receptors and metabolic pathways, are used in investigating patients with known or suspected cancers. Radionuclide imaging techniques have superior sensitivity compared to anatomic techniques and provide functional/metabolic information. However […]

Dr Gopinanth Gnanasegaran, Dr Alexis Corrigan, Christopher Sibley-Allen, Dr Kanhaiyalal Agrawal

Guy's and St Thomas' Hospital NHS Foundation Trust

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