The voice of medical imaging and clinical oncology

Alp Notghi

123I-Ioflupane progression studies – avoiding pitfalls

Ioflupane (DaTSCAN) is a well established diagnostic tool for diagnosis of Parkinson’s disease (PD), as well as dementia with Lewy bodies (DLB). Ioflupane binds to the dopamine active transporters in the presynaptic membrane of the dopaminergic nerve terminals (DNT). Dopaminergic pathways in the brain are involved in various brain functions. Degeneration of dopaminergic neurons in […]

Dr Alp Notghi, Mr Joseph O'Brien

City Hospital

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SPECT V/Q with Kr81m gas and Tc99m MAA dual energy imaging

Lung SPECT V/Q has now superseded planar imaging as the standard modality. The benefits of SPECT over planar are clear, with sensitivity, specificity and accuracy matching that of computed tomography pulmonary angiography (CTPA). SPECT V/Q can be carried out with Tc99m MAA for perfusion and Tc99m aerosol for ventilation. However, these two studies must be […]

Bill Thomson, Joseph O'Brien, Manish Pandit, Greg James, Alex Neale, Alp Notghi

City Hospital, Birmingham

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