Ioflupane (DaTSCAN) is a well established diagnostic tool for diagnosis of Parkinson’s disease (PD), as well as dementia with Lewy bodies (DLB). Ioflupane binds to the dopamine active transporters in the presynaptic membrane of the dopaminergic nerve terminals (DNT). Dopaminergic pathways in the brain are involved in various brain functions. Degeneration of dopaminergic neurons in […]
Dr Alp Notghi, Mr Joseph O'Brien
City Hospital
Mono-arthritis may be a presenting feature for a variety of inflammatory arthopathies such as those associated with rheumatoid arthritis or psoriatic arthritis. Such patients can be troubled by a single persistently inflamed and swollen joint when other involved joints have improved in response to systemic therapy (eg methotrexate). Such persisting synovitis, involving excess growth of […]
J O'Brien, Dr W H Thomson, J Croasdale, Dr D Situnayake, N B Smith
City Hospital, Sandwell and West Birmingham Hospitals NHS Trust
Lung SPECT V/Q has now superseded planar imaging as the standard modality. The benefits of SPECT over planar are clear, with sensitivity, specificity and accuracy matching that of computed tomography pulmonary angiography (CTPA). SPECT V/Q can be carried out with Tc99m MAA for perfusion and Tc99m aerosol for ventilation. However, these two studies must be […]
Bill Thomson, Joseph O'Brien, Manish Pandit, Greg James, Alex Neale, Alp Notghi
City Hospital, Birmingham